Prop-2-en-1-yl 4-aminobenzoate → 4-[({(2S,4R)-1-[(3-chloro-4-fluoro-1-methyl-1H-indol-5-yl)carbonyl]-4-[1-(methylsulfonyl)-4-piperidinyl]-2-pyrrolidinyl}carbonyl)amino]benzoic acid

반응식

CC(O[C:6]([N:8]1[CH2:12][C@@H:11]([CH:13]2[CH2:18][CH2:17][N:16]([S:19]([CH3:22])(=[O:21])=[O:20])[CH2:15][CH2:14]2)[CH2:10][C@H:9]1[C:23]([OH:25])=[O:24])=[O:7])(C)C.[NH2:26][C:27]1[CH:38]=[CH:37][C:30]([C:31]([O:33][CH2:34][CH:35]=[CH2:36])=[O:32])=[CH:29][CH:28]=1.[Cl:39][C:40]1[C:48]2[C:43](=[CH:44][CH:45]=[C:46]([C:50]([OH:52])=O)[C:47]=2[F:49])[N:42]([CH3:53])[CH:41]=1>[Pd]>[Cl:39][C:40]1[C:48]2[C:43](=[CH:44][CH:45]=[C:46]([C:6]([N:8]3[CH2:12][C@@H:11]([CH:13]4[CH2:14][CH2:15][N:16]([S:19]([CH3:22])(=[O:20])=[O:21])[CH2:17][CH2:18]4)[CH2:10][C@H:9]3[C:23]([NH:26][C:27]3[CH:28]=[CH:29][C:30]([C:31]([O:33][CH2:34][CH:35]=[CH2:36])=[O:32])=[CH:37][CH:38]=3)=[O:25])=[O:7])[C:47]=2[F:49])[N:42]([CH3:53])[CH:41]=1.[Cl:39][C:40]1[C:48]2[C:43](=[CH:44][CH:45]=[C:46]([C:50]([N:8]3[CH2:12][C@@H:11]([CH:13]4[CH2:18][CH2:17][N:16]([S:19]([CH3:22])(=[O:21])=[O:20])[CH2:15][CH2:14]4)[CH2:10][C@H:9]3[C:23]([NH:26][C:27]3[CH:28]=[CH:29][C:30]([C:31]([OH:33])=[O:32])=[CH:37][CH:38]=3)=[O:24])=[O:52])[C:47]=2[F:49])[N:42]([CH3:53])[CH:41]=1