Dimethylamine → 3-Hydroxy-N,N,2-trimethylbenzamide

HRID 1053872

반응식

HRID 1053872 반응식
[OH:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].[CH3:12][NH:13][CH3:14]>>[OH:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([N:13]([CH3:14])[CH3:12])=[O:6]

참가 물질

3

반응물 2

HCID 674DimethylamineHCID 2520233-Hydroxy-2-methylbenzoic Acid

생성물 1

HCID 577538383-Hydroxy-N,N,2-trimethylbenzamide수율 42%

실험 절차

The title compound was prepared from 3-hydroxy-2-methylbenzoic acid and dimethylamine, using the same method as that described for preparation 75, as a solid in 42% yield. 1H NMR (400 MHz, CDCl3) δ: 1.95 (s, 3H), 2.70 (s, 3H), 2.95 (s, 3H), 6.55 (d, 1H), 6.80 (d, 1H), 7.00 (m, 1H), 9.50 (s, 1H); LRMS APCI m/z 180 [M+H]+

후처리

  1. customthat described for preparation 75, as a solid in 42% yield

출처 및 근거

ORD 기록
ord-a07d33d2d4474f7fab44201ee581f098
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394278B2

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