Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → 3-(Bromomethyl)-6-phenylpyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 3-Methyl-6-phenylpyridazine | HCID 11378744 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 3-(Bromomethyl)-6-phenylpyridazine | HCID 66717445 | — |
반응 단계
Synthesized using compound 65b (982 mg, 5.77 mmol), NBS (1.13 g, 6.35 mmol) and DBPO (70 mg, 0.29 mmol) in carbon tetrachloride according to Method A. Crude product was purified by flash chromatography on silica-gel using hexane/ethyl acetate (4:1) as eluent. Product was used directly in the next step without further characterization. Orange solid. Yield: 53 mg, 4%. (ESI): m/z=250.67 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09394290B2 |
| 출처 데이터셋 | uspto-grants-2016_07 |
| ORD ID | ord-e12083880c59418886cef06b3e62e0f5 |
| 출처 메모 | uspto-grants-2016_07 |