1-Isocyano-4-(methoxycarbonyl)benzene → HCID 89501782, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:36]2[CH:40]=[N:39][N:38]=[N:37]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([CH3:22])[CH:18]=3)[CH:13]2[C:23]([NH:25][C:26]2[CH:35]=[CH:34][C:29]([C:30]([O:32]C)=[O:31])=[CH:28][CH:27]=2)=[O:24])=[O:11])[CH:7]=1.[N+](C1C=CC(C(OC)=O)=CC=1)#[C-]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:36]2[CH:40]=[N:39][N:38]=[N:37]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([CH3:22])[CH:18]=3)[CH:13]2[C:23]([NH:25][C:26]2[CH:35]=[CH:34][C:29]([C:30]([OH:32])=[O:31])=[CH:28][CH:27]=2)=[O:24])=[O:11])[CH:7]=1참가 물질
4
실험 절차
(E)-Methyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-6-methyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate: To 20B (0.15 g, 1.033 mmol), methyl 4-isocyanobenzoate (0.166 g, 1.033 mmol), and Intermediate 2 (0.259 g, 1.033 mmol) was added MeOH (20 mL). The reaction was heated to reflux for 24 h. After cooling to rt the product was filtered off as (0.318 g, 55.3%) a yellow solid. MS (ESI) m/z: 557.0 (M+H)+.