Stannous chloride dihydrate → 5-Amino-1-chloroisoquinoline

온도

70 °C

A solution (40 ml) of 1-chloro-5-nitroisoquinoline (2.23 g, synthesized according to the method described in J. Med. Chem. 45, 3, 740 (2002)) in ethyl acetate was added with tin(II) chloride dihydrate (12.39 g, Wako Pure Chemical Industries) at room temperature and stirred with heating at 70° C. for 1 hour. The reaction mixture was cooled to room temperature, then added with ice (200 g) and stirred for 0.5 hour. The reaction mixture was filtered through Celite and extracted three times with ethyl acetate (200 ml for each time), and the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1) to obtain the title compound (749 mg).

1. temperatureThe reaction mixture was cooled to room temperature
2. stirringstirred for 0.5 hour
3. filtrationThe reaction mixture was filtered through Celite
4. extractionextracted three times with ethyl acetate (200 ml for each time), and the organic layer
5. dry with materialwas dried over anhydrous sodium sulfate
6. customThe solvent was evaporated under reduced pressure
7. customthe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1)

ORD 기록

ord-c2c568e79a76424c86ebc38f97226234

출처 데이터셋

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07094789B2