Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate → [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol

HRID 1054226

반응식

HRID 1054226 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8](OCC)=[O:9])[N:7]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[F:14][C:2]([F:1])([F:13])[C:3]1[S:4][CH:5]=[C:6]([CH2:8][OH:9])[N:7]=1

참가 물질

4

반응물 2

HCID 20079591Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 20079604[2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol수율 56%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirring solution of ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (1.0 g, 4.44 mmol) in THF (10 ml) was added LiAlH4 (0.169 g, 4.44 mmol) at 0-10° C. and stirred for 1 h at RT. Reaction mixture was cooled and quenched with saturated sodium sulfate solution till precipitates observed. Precipitates obtained were filtered and filtrate was evaporated to get desired product in 56% yield.

후처리

  1. customReaction mixture
  2. temperaturewas cooled
  3. customquenched with saturated sodium sulfate solution
  4. customtill precipitates
  5. customPrecipitates
  6. customobtained
  7. filtrationwere filtered
  8. customfiltrate was evaporated

출처 및 근거

ORD 기록
ord-d0e96f6c79d24a58a222558e0a7838af
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394300B2

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