Ethyl isothiocyanatoformate → 1-(6-Bromo-4-methyl-pyridin-2-yl)-3-carboethoxy-thiourea
반응식
[Br:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH3:9])[CH:3]=1.[CH2:10]([O:12][C:13]([N:15]=[C:16]=[S:17])=[O:14])[CH3:11]>ClCCl>[Br:1][C:2]1[N:7]=[C:6]([NH:8][C:16]([NH:15][C:13]([O:12][CH2:10][CH3:11])=[O:14])=[S:17])[CH:5]=[C:4]([CH3:9])[CH:3]=1참가 물질
4
실험 절차
To a solution of 6-bromo-4-methyl-pyridin-2-ylamine (0.5 g, 2.67 mmol) in dichloromethane (20 ml) cooled to 5° C. was added ethoxycarbonyl isothiocyanate (0.32 ml, 2.67 mmol) dropwise over 15 min. The reaction mixture was then allowed to warm to room temperature at which it was stirred for 16 h. Evaporation in vacuo gave a solid that was collected by filtration and thoroughly washed with cyclohexane to give the desired product. Yield 0.59 g, 69%. LCMS MI: 317.92+319.94, RT: 5.05 min, Method: 2