Water → 3-Bromo-6-chloro-2-methoxypyridine

HRID 1054867

반응식

HRID 1054867 반응식
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[CH3:10][O-:11].[Na+].O>C(#N)C>[Br:1][C:2]1[C:3]([O:11][CH3:10])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 215518193-Bromo-2,6-dichloropyridine

생성물 1

HCID 532174543-Bromo-6-chloro-2-methoxypyridine수율 93.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.

후처리

  1. customthe organic was evaporated
  2. filtrationThe resulting suspension was filtered
  3. washthe pad was washed with water for several times
  4. customThe pad was dried

출처 및 근거

ORD 기록
ord-6f02dd56485b4c9cbf12cee0cded4e36
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394285B2

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