HCID 90017318, 화합물 → HCID 90018297, 화합물

HRID 1054998노트

반응식

HRID 1054998 반응식
COC1C=CC(C[NH:8][C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:12]=[C:11]([CH3:19])[N:10]=2)=CC=1>FC(F)(F)C(O)=O>[CH3:19][C:11]1[N:10]=[C:9]([NH2:8])[C:14]([C:15]([F:18])([F:16])[F:17])=[CH:13][CH:12]=1

참가 물질

3

반응물 1

HCID 90017318HCID 90017318, 화합물

생성물 1

HCID 90018297HCID 90018297, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

N-(4-Methoxybenzyl)-6-methyl-3-(trifluoromethyl)pyridin-2-amine (100 mg, 338 μmol, Eq: 1.00) in trifluoroacetic acid (2 ml) was heated under reflux for 30 min. The mixture was concentrated. The crude product (120 mg, pink solid) was used in the next step without further purification. MS: m/z=218.2 (M+H+)

후처리

  1. temperatureunder reflux for 30 min
  2. concentrationThe mixture was concentrated
  3. customThe crude product (120 mg, pink solid) was used in the next step without further purification

출처 및 근거

ORD 기록
ord-f692e6c33e7346948fe289090a178efd
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394311B2

반응 노트

불러오는 중…