Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 4-Chloroisoquinolin-5-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | 4-Chloro-5-nitroisoquinoline | HCID 21979967 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 4-Chloroisoquinolin-5-amine | HCID 21979937 | 67.5% |
반응 단계
Tin(II) chloride dihydrate (1.70 g) was dissolved in concentrated hydrochloric acid (1 ml), added with a mixture of Intermediate 89 (315 mg) and 2 N aqueous hydrochloric acid (2 ml) with ice cooling and refluxed with heating for 2 hours. The reaction mixture was cooled to room temperature, added with 5 N aqueous sodium hydroxide (7 ml) and extracted twice with chloroform (20 ml for each time). The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain the title compound (182 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094789B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-fcdc390576094c1d8a9ce9abd10a933f |
| 출처 메모 | uspto-grants-2006_08 |