Dipropylamine → 3-Oxo-n,n-dipropylbutanamide

HRID 1055190

반응식

HRID 1055190 반응식
[CH2:1]([NH:4][CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3].[CH2:8]=[C:9]1[O:13][C:11](=[O:12])[CH2:10]1>CO>[O:13]=[C:9]([CH3:8])[CH2:10][C:11]([N:4]([CH2:5][CH2:6][CH3:7])[CH2:1][CH2:2][CH3:3])=[O:12]

참가 물질

4

반응물 2

HCID 8902DipropylamineHCID 12661Diketene

생성물 1

HCID 2492073-Oxo-n,n-dipropylbutanamide수율 86.3%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
0 °C

실험 절차

A solution of 27.80 g (0.28 mol) N,N-di-n-propylamine was added dropwise to a solution of 20.00 g (0.24) diketene in 100 ml MeOH at 0° C. After stirring for 3 hours at 0° C., no starting material was detected anymore by thin-layer chromatography. The reaction mixture was spun off and the residue was purified by means of column chromatography. 38.05 g of product was obtained as a slightly yellow oil.

후처리

  1. customthe residue was purified by means of column chromatography

출처 및 근거

ORD 기록
ord-907516ec60ca4c8080ab426f6dc95afd
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394324B2

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