Water → HCID 90037382, 화합물

HRID 1055412노트

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HRID 1055412 반응식
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:11]#[N:12].F[C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[C:16]#[N:17].C([O-])([O-])=O.[Cs+].[Cs+].O>CN(C=O)C>[C:16]([C:15]1[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=1[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2]([CH3:1])=[C:3]1[C:11]#[N:12])#[N:17]

참가 물질

6

반응물 4

HCID 962WaterHCID 10796Cesium carbonateHCID 678552-FluorobenzonitrileHCID 5933713-Methyl-1H-indole-2-carbonitrile

생성물 1

HCID 90037382HCID 90037382, 화합물수율 94.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

A mixture of 3-methyl-1H-indole-2-carbonitrile (500 mg, 3.2 mmol), 2-fluorobenzonitrile (388 mg, 3.2 mmol) and Cs2CO3 (1.05 g, 3.2 mmol) in DMF (10 mL) was heated at 60° C. overnight. The mixture was poured into H2O and a precipitate formed. The solid was collected by filtration, washed with H2O and hexane, and dried under vacuum to give 1-(2-cyanophenyl)-3-methyl-1H-indole-2-carbonitrile (780 mg, 94.6%) as an off white solid that was used without purification.

후처리

  1. customa precipitate formed
  2. filtrationThe solid was collected by filtration
  3. washwashed with H2O and hexane
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-64051bb5bd894dc69ab7f1c804b95350
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394263B2

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