Uracil → 5-Iodouracil

HRID 1055624노트

반응식

HRID 1055624 반응식
N1C=CC(=O)NC1=O.[I:9][C:10]1[C:11](=[O:21])[NH:12][C:13](=[O:20])[N:14](CC(O)=O)[CH:15]=1.C(C(N)CNCC(OCC)=O)(OC(C)(C)C)=O>>[I:9][C:10]1[C:11](=[O:21])[NH:12][C:13](=[O:20])[NH:14][CH:15]=1

참가 물질

4

반응물 3

HCID 1174UracilHCID 1361763(5-Iodo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetic acidHCID 57253309HCID 57253309, 화합물

생성물 1

HCID 696725-Iodouracil

실험 절차

The PNA trimer can be synthesized manually or in an automated peptide synthesizer. The synthesis of universal base PNA monomer has been reported in the literature129,130 The modified uracil PNA monomer may be synthesized starting from 5-iodouracil-1-acetic acid.131 The starting material reacts with ethyl N-[2-Boc-aminoethyl]glycinate, providing a 5-iodouracil PNA monomer that can be converted into the desired product through the Sonogashira coupling132 with 3-benzoylthio-1-propyne followed by treating with di-tbutyl-1-(tbutylthio)hydrazine-1,2-dicarboxylate.34

후처리

  1. customThe synthesis of universal base PNA monomer
  2. custommay be synthesized

출처 및 근거

ORD 기록
ord-a69cfa82f3f64dcfbab481e5f1e4a4f6
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09395352B2

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