1-(2,2-Diethoxyethyl)-1'-(4-methoxybenzyl)-1H,1'H-3,4'-bipyrazol-5-amine → HCID 178490761, 화합물

HRID 1055633

반응식

HRID 1055633 반응식
C(O[CH:4](OCC)[CH2:5][N:6]1[C:10]([NH2:11])=[CH:9][C:8]([C:12]2[CH:13]=[N:14][N:15]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[CH:16]=2)=[N:7]1)C>C(O)C.S(=O)(=O)(O)O>[CH3:25][O:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:15]2[CH:16]=[C:12]([C:8]3[CH:9]=[C:10]4[NH:11][CH:4]=[CH:5][N:6]4[N:7]=3)[CH:13]=[N:14]2)=[CH:19][CH:20]=1

참가 물질

4

반응물 1

HCID 866909601-(2,2-Diethoxyethyl)-1'-(4-methoxybenzyl)-1H,1'H-3,4'-bipyrazol-5-amine

생성물 1

HCID 178490761HCID 178490761, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 1118Sulfuric Acid용매

실험 절차

In a microwave oven (Biotage Initiator, with Dynamic Field Tuning), 155 mg (0.40 mmol) of the compound of Example 2A in 0.4 ml of ethanol and 0.2 ml of 2 M sulphuric acid were heated at 120° C. for 15 min. The reaction was then purified directly by preparative HPLC (Method 11). The product fractions were concentrated and the residue was dried under high vacuum. This gave 54 mg (46% of theory) of the title compound.

후처리

  1. customThe reaction was then purified directly by preparative HPLC (Method 11)
  2. concentrationThe product fractions were concentrated
  3. customthe residue was dried under high vacuum

출처 및 근거

ORD 기록
ord-f72c1db23d20489c994c6c8744136b83
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394309B2

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