3-(4-Methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid trifluoroacetate → N-(3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-3-(4-methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

HRID 1055671노트

반응식

HRID 1055671 반응식
[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=5[CH3:28])[NH2:24])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:5][CH:4]=1.FC(F)(F)C(O)=O.[CH3:39][N:40]1[CH2:45][CH2:44][N:43]([C:46]2[CH:47]=[C:48]([CH:52]=[C:53]([S:55]([F:60])([F:59])([F:58])([F:57])[F:56])[CH:54]=2)[C:49](O)=[O:50])[CH2:42][CH2:41]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([NH:24][C:49](=[O:50])[C:48]6[CH:52]=[C:53]([S:55]([F:60])([F:56])([F:57])([F:58])[F:59])[CH:54]=[C:46]([N:43]7[CH2:42][CH2:41][N:40]([CH3:39])[CH2:45][CH2:44]7)[CH:47]=6)[CH:25]=[CH:26][C:27]=5[CH3:28])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:30][CH:31]=1

참가 물질

3

반응물 2

HCID 896995603-(4-Methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid trifluoroacetateHCID 896998613-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline

생성물 1

HCID 89699504N-(3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-3-(4-methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

실험 절차

70 mg (0.17 mmol) of the compound of Example 9A and 78 mg (0.17 mmol) of the compound of Example 17A were reacted and worked up analogously to the procedure of Example 48A. This gave 125 mg (95% of theory) of the title compound.

출처 및 근거

ORD 기록
ord-f7b7093cbb9b46f4bc8e89567ca48434
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394309B2

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