3-Methyl-5-(pentafluorosulfur)benzoic acid → HCID 89699775, 화합물

반응식

[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.[CH3:23][C:24]1[CH:25]=[C:26]([CH:30]=[C:31]([S:33]([F:38])([F:37])([F:36])([F:35])[F:34])[CH:32]=1)[C:27](O)=[O:28]>>[CH3:23][C:24]1[CH:25]=[C:26]([CH:30]=[C:31]([S:33]([F:36])([F:34])([F:35])([F:37])[F:38])[CH:32]=1)[C:27]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[CH:4]=1)=[O:28]

참가 물질

반응물 2

HCID 665235893-Methyl-5-(pentafluorosulfur)benzoic acid

HCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

생성물 1

HCID 89699775HCID 89699775, 화합물

실험 절차

Analogously to the process described in Example 26, 80 mg (0.276 mmol) of the compound of Example 6A and 73 mg (0.276 mmol) of the compound of Example 34A gave 101 mg (61% of theory, 90% pure) of the title compound.

출처 및 근거

ORD 기록: ord-e1e0f89ddaab4dfeb339b2c733c0971e
출처 데이터셋: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09394309B2

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