Stannane, tributyl(1-ethoxyethenyl)- → 8-(1-Ethoxyvinyl)-2-phenylquinoline

HRID 1056055노트

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HRID 1056055 반응식
Br[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:8]=[CH:7]2.C([Sn](CCCC)(CCCC)[C:23]([O:25][CH2:26][CH3:27])=[CH2:24])CCC>C1(C)C=CC=CC=1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH2:26]([O:25][C:23]([C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:8]=[CH:7]2)=[CH2:24])[CH3:27]

참가 물질

5

반응물 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 707004958-Bromo-2-phenylquinoline

생성물 1

HCID 897820818-(1-Ethoxyvinyl)-2-phenylquinoline

시약·촉매·용매 2

HCID 178418476HCID 178418476, 화합물촉매HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

In a sealed tube, to the suspension of 8-bromo-2-phenylquinoline (0.1 g, 0.352 mmol) in toluene (5 mL) was added PdCl2(PPh3)2 (0.012 g, 0.017 mmol) and tributyl (1-ethoxyvinyl)stannane (0.15 g, 0.422 mmol) under N2. The reaction was heated at 80° C. for 12 h, then cooled to RT. The solvent was removed and the crude material was used in the next step without further purification.

후처리

  1. temperaturecooled to RT
  2. customThe solvent was removed
  3. customthe crude material was used in the next step without further purification

출처 및 근거

ORD 기록
ord-3b2faf61259145aea56ce4f3fa242058
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394297B2

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