참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyruvic Acid | HCID 1060 | — |
| 반응물 | 2-Chloropyridine-3,4-diamine | HCID 285736 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | HCID 178432270 | HCID 178432270 | 65.7% |
반응 단계
A mixture of 3,4-diamino-2-chloropyridine (2.1 g, 14.63 mmol) (Sigma Aldich) and pyruvic acid (1.22 mL, 17.55 mmol) (Acros, New Jersey) in MeOH (40 mL) in a sealed glass tube was heated at 50° C. for 2 h. The mixture was cooled to RT and the solvent was removed in vacuo. The residue was triturated with ether and the suspension was filtered to give 1.88 g of crude product. MS (ESI, pos. ion) m/z: 196.1 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09394297B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_07 |
|---|
| ORD ID | ord-5c3cc1e123fc447d8c33780bcb59abdc |
|---|
| 출처 메모 | uspto-grants-2016_07 |
|---|
