Methyl Decanoate → Vanillyl decanoate

HRID 1056461

반응식

HRID 1056461 반응식
[CH3:1][O:2][C:3](=[O:13])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(O)[C:15]1[CH:23]=[CH:22][C:20]([OH:21])=[C:17]([O:18][CH3:19])[CH:16]=1>CC(C)=O>[C:3]([O:2][CH2:1][C:15]1[CH:23]=[CH:22][C:20]([OH:21])=[C:17]([O:18][CH3:19])[CH:16]=1)(=[O:13])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 8050Methyl DecanoateHCID 62348Vanillyl alcohol

생성물 1

HCID 15979852Vanillyl decanoate수율 73%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

This compound was synthesized by the method described in Kobata et al. (Biosci. Biotechnol. Biochem., 66(2), 319-327, 2002). Decanoic acid methyl ester (2.13 mL, 10.5 mmol), vanillyl alcohol (1.62 g, 10.5 mmol), molecular sheaves 4 Å (10 g), and Novozyme 435 (2.5 g) were added to acetone (50 mL) and stirred for 2 hours at room temperature. The reaction solution was filtered through cellite and the filtrate was concentrated under reduced pressure. The concentrated residue was purified by silica gel chromatography, yielding 2.25 g (7.30 mmol, 73.0 percent) of vanillyl decanoate in the form of a colorless oily substance.

후처리

  1. customThis compound was synthesized by the method
  2. filtrationThe reaction solution was filtered through cellite
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe concentrated residue was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-11ad05997a0a4c39bef970dce0378f1a
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09399030B2

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