Dichloromethane → HCID 18629485, 화합물

HRID 1056575노트

반응식

HRID 1056575 반응식
[C:1]([O:5][C:6]([NH:8][CH:9]([CH:13]([CH3:15])[CH3:14])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[CH2:21](Cl)[Cl:22]>O>[C:1]([O:5][C:6]([NH:8][CH:9]([CH:13]([CH3:15])[CH3:14])[C:10]([O:12][CH2:21][Cl:22])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6344Dichloromethane2회HCID 270655Boc-DL-valineHCID 516892Sodium Bicarbonate

생성물 1

HCID 18629485HCID 18629485, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound was prepared according to the procedure as described in Example 17 Step 1 using 2-((tert-butoxycarbonyl)amino)-3-methylbutanoic acid (1 g, 4.6 mmol) in DCM (25 mL) and H2O (25 mL), NaHCO3 (1.55 g, 18.4 mmol), TBAHSO4 (156 mg, 0.46 mmol) and a solution of chloromethyl sulfochloridate (559 μL, 5.5 mmol) in DCM (5 mL). The title compound was obtained as colorless oil (877 mg, 71.8%). The title compound was characterized by 1H NMR as shown below:

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-2298ed8be94b4840b5a0d817f6208c1f
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09399639B2

반응 노트

불러오는 중…