Dichloromethane → Chloromethyl 2-{[(tert-butoxy)carbonyl]amino}acetate

HRID 1056577노트

반응식

HRID 1056577 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[CH2:18](Cl)[Cl:19]>O>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([O:12][CH2:18][Cl:19])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 6344Dichloromethane2회HCID 78288N-(tert-butoxycarbonyl)glycineHCID 516892Sodium Bicarbonate

생성물 1

HCID 12968718Chloromethyl 2-{[(tert-butoxy)carbonyl]amino}acetate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound was prepared according to the procedure as described in Example 17 Step 1 using 2-((tert-butoxycarbonyl)amino)acetic acid (1 g, 5.7 mmol) in DCM (25 mL) and H2O (25 mL), NaHCO3 (1.92 g, 22.8 mmol), TBAHSO4 (194 mg, 0.57 mmol) and a solution of chloromethyl sulfochloridate (693 mL, 6.8 mmol) in DCM (5 mL). The title compound was obtained as colorless oil (911 mg, 71.3%).

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-0088c5696bdd4a198c42c89ac1a3e887
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09399639B2

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