2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one → 2-chloro-4H-benzo[d][1,3,2]dioxaphosphinine 2-oxide

반응식

N1C=CC=CC=1.[O:7]1[CH2:12][CH2:11]OCC1.[Cl:13][P:14]1[O:19]C(=O)[C:17]2[CH:21]=[CH:22][CH:23]=C[C:16]=2[O:15]1>O1CCOCC1>[Cl:13][P:14]1(=[O:19])[O:15][CH2:16][C:17]2[CH:21]=[CH:22][CH:23]=[CH:11][C:12]=2[O:7]1

참가 물질

실험 절차

Add into a vial first 2 mL of pyridine/dioxane, 3:1 v/v followed by 100 μL of 1 M 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one solution in dry dioxane to give a 50 mM solution of the phosphitylating reagent, e.g. 2-chloro-4H-1,3,2-benzodioxaphosphorin-2-one, in dioxane/pyridine, 3:1 (v/v). Homogenize the solution by gently shaking. Start the reaction by drawing the 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one solution through the synthesis column from the vial.