Dichloromethane → 7-(2-Carboxyvinyl)-4-(4-chloro-2-fluorophenoxy)-6-methoxyquinazoline

반응식

[CH2:31]([Cl:32])[Cl:33].[Cl:1][c:2]1[cH:3][c:4]([F:30])[c:5]([O:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([CH:19]=[CH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:28][cH:29]1.[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40]>>[Cl:1][c:2]1[cH:3][c:4]([F:30])[c:5]([O:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([CH:19]=[CH:20][C:21](=[O:22])[OH:23])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:28][cH:29]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 540046344-(4-Chloro-2-fluorophenoxy)-6-methoxy-7-(2-(tert-butoxycarbonyl)vinyl)quinazoline

생성물 1

HCID 541944267-(2-Carboxyvinyl)-4-(4-chloro-2-fluorophenoxy)-6-methoxyquinazoline

출처 및 근거

ORD 기록: ord-0bf8caa367e64fc6bdf2e221a7aa8839
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

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