Potassium Carbonate → 1-Butyl-5-ethyluracil

HRID 1057253

반응식

HRID 1057253 반응식
[CH2:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:2]([N:7]1[CH:8]=[C:3]([CH2:1][CH3:2])[C:4](=[O:10])[NH:5][C:6]1=[O:9])[CH2:1][CH2:3][CH3:8]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 732675-Ethyl-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 186710321-Butyl-5-ethyluracil수율 69%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

To a solution of 5.6 g (40 mmol) of 5-ethyluracil in 60 ml of dimethylformamide, 5.5 g (40 mmol) of potassium carbonate and 2.3 ml (20 mmol) of n-iodobutane were added and stirred for 2 hours at 120° C. The reaction mixture was concentrated under reduced pressure and distributed between dichloromethane and aqueous solution of ammonium chloride, and the organic layer was concentrated under reduced pressure. The residue was adsorbed on a silica gel column and eluted with 30% ethyl acetate/hexane to obtain 2.7 g of 1-butyl-5-ethyluracil (Yield: 69%).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. concentrationthe organic layer was concentrated under reduced pressure
  3. washeluted with 30% ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-536f8196f59441eb9dc123a8eaaba2eb
출처 데이터셋
uspto-grants-2003_02
특허 번호
USRE037979E1

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