HCID 178418777, 화합물 → HCID 178418696, 화합물

HRID 10573

반응식

HRID 10573 반응식
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([CH:26]=[CH2:27])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pt]=O>[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([CH2:26][CH3:27])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 178418777HCID 178418777, 화합물

생성물 1

HCID 178418696HCID 178418696, 화합물수율 45.2%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매

실험 절차

A solution of Intermediate 124 (90.5 mg) in methanol (5 ml) was added with platinum oxide (13 mg, Wako Pure Chemical Industries) and stirred for 15 hours under hydrogen atmosphere. The reaction mixture was filtered through a Celite layer, and the solvent was evaporated under reduced pressure. Then, the residue was purified by silica gel column chromatography (chloroform:methanol=20:1) to obtain the title compound (41.1 mg).

후처리

  1. filtrationThe reaction mixture was filtered through a Celite layer
  2. customthe solvent was evaporated under reduced pressure
  3. customThen, the residue was purified by silica gel column chromatography (chloroform:methanol=20:1)

출처 및 근거

ORD 기록
ord-41aab4904af540338d435ca329ed8c84
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

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