7-Benzyloxy-4-chloro-6-methoxycinnoline hydrochloride → 4-Chloro-7-hydroxy-6-methoxycinnoline

HRID 1057332

반응식

HRID 1057332 반응식
Cl.C([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([Cl:20])=[CH:15][N:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[Cl:20][C:14]1[C:13]2[C:18](=[CH:19][C:10]([OH:9])=[C:11]([O:21][CH3:22])[CH:12]=2)[N:17]=[N:16][CH:15]=1

참가 물질

3

반응물 1

HCID 219910077-Benzyloxy-4-chloro-6-methoxycinnoline hydrochloride

생성물 1

HCID 1357525234-Chloro-7-hydroxy-6-methoxycinnoline수율 94%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

The starting material, 4-chloro-7-hydroxy-6-methoxycinnoline was obtained by heating a solution of 7-benzyloxy-4-chloro-6-methoxycinnoline hydrochloride (3.06 g, 9 mmol), (prepared as described for the starting material in Example 6), in TFA (30 ml) at reflux for 5 hours. After evaporation of the solvent, the residue was suspended in water and adjusted to pH7 with saturated aqueous sodium hydrogen carbonate solution. The resulting solid was filtered off, washed with water and ether and dried under vacuum to give 4-chloro-7-hydroxy-6-methoxycinnoline as a yellow solid (1.78 g, 94%).

후처리

  1. custom(prepared
  2. temperatureat reflux for 5 hours
  3. customAfter evaporation of the solvent
  4. filtrationThe resulting solid was filtered off
  5. washwashed with water and ether
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-7a2a5ada340e43df8378062cf1a3e475
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06514971B1

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