Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 5-Amino-4-fluoro-2-methylphenol | HCID 10154098 | — |
| 반응물 | 4-Chloro-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline | HCID 21991061 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | 2-Pentanol | HCID 22386 | — |
| 생성물 | 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline hydrochloride | HCID 21991028 | 89.2% |
반응 단계
A suspension of 4-chloro-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline (150 mg, 0.46 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (78 mg, 0.56 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (3 ml) and a 5M solution of hydrogen chloride in isopropanol (105 μl) was heated at reflux for 90 minutes. The solid obtained was filtered off, washed with isopropanol followed by ether to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline hydrochloride as a pale yellow solid (190 mg, 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06514971B1 |
| 출처 데이터셋 | uspto-grants-2003_02 |
| ORD ID | ord-4783bb1bc2b7418096c3ac2ef95bd9db |
| 출처 메모 | uspto-grants-2003_02 |