Bromoacetic Acid → 2-(3-{[N-(3-(1,2,3,4-tetrahydropyridino[2,3-b]pyridin-7-yl)propyl)carbamoyl]methyl}-1H,2H,4H,5H-benzo[d]azepinyl)acetic acid

참여 물질

역할	이름	HCID	투입량
반응물	Bromoacetic Acid	HCID 6227	—
반응물	3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine	HCID 9877599	—
반응물	HCID 18671414	HCID 18671414	—
생성물	2-(3-{[N-(3-(1,2,3,4-tetrahydropyridino[2,3-b]pyridin-7-yl)propyl)carbamoyl]methyl}-1H,2H,4H,5H-benzo[d]azepinyl)acetic acid	HCID 9932757	—

반응 단계

2-(3-{[N-(3-(1,2,3,4-tetrahydropyridino[2,3-b]pyridin-7-yl)propyl)carbamoyl]methyl}-1H,2H,4H,5H-benzo[d]azepinyl)acetic acid was prepared from bromoacetic acid, 3-(1,2,3,4-tetrahydropyridino[2,3,b]pyridin-7-yl)propylamine and methyl 2-(1H,2H,3H,4H,5H-benzo[d]azepin-1-yl)acetate according to the procedure of Example 27. EI-MS m/z 437 (M+H)+; 1H NMR (400 MHz; CDCl3): 9.61 (1H, br), 8.39 (1H, br), 7.15 (5H, m), 6.31 (1H, d, J=7.25 Hz), 3.64 (2H, m), 3.34 (6H, m), 2.99 (4H, m), 2.71 (4H, m), 1.93 (5H, m), 0.86 (2H, m).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06514964B1
출처 데이터셋	uspto-grants-2003_02
ORD ID	ord-814bff23bce74268ab43ea2ae5b91b88
출처 메모	uspto-grants-2003_02