7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine → 5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbaldehyde

HRID 1057502노트

반응식

HRID 1057502 반응식
C[O:2][CH:3](OC)[C:4]1[N:9]=[C:8]2[NH:10][CH2:11][CH2:12][CH2:13][C:7]2=[CH:6][CH:5]=1>FC(F)(F)C(O)=O>[NH:10]1[C:8]2=[N:9][C:4]([CH:3]=[O:2])=[CH:5][CH:6]=[C:7]2[CH2:13][CH2:12][CH2:11]1

참가 물질

3

반응물 1

HCID 177501767-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

생성물 1

HCID 218737255,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbaldehyde

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

Dimethoxy-1,2,3,4-tetrahydropyridino[2,3-b]pyridin-7-ylmethane was dissolved in trifluoroacetic acid (14 mL) and stirred under nitrogen for 16 hrs. The mixture was quenched with saturated sodium bicarbonate, extracted with methylene chloride, dried over sodium sulfate, filtered, in vacuo and purified by flash chromatography (5% MeOH/CH2Cl2 ). EI-MS m/z 163 (M+H)+.

후처리

  1. customThe mixture was quenched with saturated sodium bicarbonate
  2. extractionextracted with methylene chloride
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered, in vacuo
  5. custompurified by flash chromatography (5% MeOH/CH2Cl2 )

출처 및 근거

ORD 기록
ord-8f6e0f92abb04482939c2ad86e76e799
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06514964B1

반응 노트

불러오는 중…