Bromine → Methyl 6-bromo-5-oxohexanoate

HRID 1057504노트

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HRID 1057504 반응식
[C:1]([CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10]C)=[O:8])(=[O:3])[CH3:2].[Br:12]Br>CO>[Br:12][CH2:2][C:1](=[O:3])[CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 2

HCID 24408BromineHCID 84130Ethyl 5-oxohexanoate

생성물 1

HCID 582216Methyl 6-bromo-5-oxohexanoate

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
0 °C

실험 절차

Ethyl 4-acetylbutyrate was dissolved in MeOH (0.5M) and cooled to 0° C. Bromine (1.0 eq) was added dropwise and the mixture was stirred at room temperature for 18 hrs. The solvent was removed in vacuo and the residue was dissolved in ether, washed with water, saturated sodium bicarbonate, brine, dried over sodium sulfate. The solvent was removed in vacuo and the residue was purified by flash chromatograpy (7% EtOAc/Hexanes). EI-MS m/z 224 (M+H)+.

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in ether
  3. washwashed with water, saturated sodium bicarbonate, brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed in vacuo
  6. customthe residue was purified by flash chromatograpy (7% EtOAc/Hexanes)

출처 및 근거

ORD 기록
ord-6f5fcd12af6c4ed4877937219857f1b5
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06514964B1

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