(R)-3-Pyrrolidinol → HCID 69356665, 화합물

HRID 1057785노트

반응식

HRID 1057785 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[NH:25]1[CH2:29][CH2:28][C@@H:27]([OH:30])[CH2:26]1>>[N:20]1([C:18]([C:15]2[CH:16]=[CH:17][C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:25]4[CH2:29][CH2:28][C@@H:27]([OH:30])[CH2:26]4)=[CH:7][CH:8]=3)=[CH:13][CH:14]=2)=[O:19])[CH2:24][CH2:23][CH2:22][CH2:21]1

참가 물질

3

반응물 2

HCID 2759337(R)-3-PyrrolidinolHCID 22994486[4'-(3-Chloropropoxy)[1,1'-biphenyl]-4-yl](pyrrolidin-1-yl)methanone

생성물 1

HCID 69356665HCID 69356665, 화합물

실험 절차

1-{[4′-(3-Chloropropoxy)[1,1′-biphenyl]-4-yl]carbonyl}pyrrolidine and (3R)-3-pyrrolidinol were processed as described in Example 159 to provide the title compound.

출처 및 근거

ORD 기록
ord-564d210332ca452b9692cc56fdb4d672
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06515013B2

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