1,2-Dichlorobenzene → 4-(4-Fluorophenoxy)-2-(prop-2-en-1-yl)phenol

반응식

C([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)C=C.Cl[C:20]1[CH:25]=CC=C[C:21]=1Cl>>[F:18][C:15]1[CH:14]=[CH:13][C:12]([O:11][C:8]2[CH:7]=[CH:6][C:5]([OH:4])=[C:10]([CH2:25][CH:20]=[CH2:21])[CH:9]=2)=[CH:17][CH:16]=1

참가 물질

반응물 2

HCID 72391,2-Dichlorobenzene

HCID 186724764-(4-Fluorophenoxy)phenyl allyl ether

생성물 1

HCID 186724734-(4-Fluorophenoxy)-2-(prop-2-en-1-yl)phenol

실험 절차

4-(4-fluorophenoxy)phenyl allyl ether (4.00 g, 16.37 mmol) was taken up in 1,2-dichlorobenzene (50 mL) and refluxed for 48 h. After cooling, the solvent was removed in vacuo and the resulting crude oil was chromatographed on silica gel (15% ethyl acetate/hexane) to afford the title compound.

후처리

temperaturerefluxed for 48 h
temperatureAfter cooling
customthe solvent was removed in vacuo
customthe resulting crude oil was chromatographed on silica gel (15% ethyl acetate/hexane)

출처 및 근거

ORD 기록: ord-75de1becd53b4cb49eaa9f0c6d77c418
출처 데이터셋: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06515015B1

반응 노트

불러오는 중…