Morpholine → 7-Methoxy-2-morpholinocarbonylbenzofuran

반응식

[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([C:12]([OH:14])=O)=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[O:14])=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 8083Morpholine

HCID 6060377-Methoxy-1-benzofuran-2-carboxylic acid

생성물 1

HCID 227338767-Methoxy-2-morpholinocarbonylbenzofuran

실험 절차

Substantially the same procedure as in Example 219 was repeated using a starting material, 7-methoxybenzofuran-2-carboxylic acid, and morpholine to give 7-methoxy-2-morpholinocarbonylbenzofuran (Compound 329a). Successively, it was formylated to give 4-formyl-7-methoxy-2-morpholinocarbonylbenzofuran (Compound 329b), then compound 329b was reacted with methylamine hydrochloride to give compound 329 as a white solid.

출처 및 근거

ORD 기록: ord-decdb80365924aabb84ca809d98d6bd2
출처 데이터셋: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06514996B2

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