Acetic Acid → 2-Cyano-7-methoxybenzofuran-4-carboxylic acid

HRID 1057933노트

반응식

HRID 1057933 반응식
[C:1]([C:3]1[O:4][C:5]2[C:6](=[C:8]([CH:14]=[O:15])[CH:9]=[CH:10][C:11]=2[O:12][CH3:13])[CH:7]=1)#[N:2].C(O)(=[O:18])C.S(=O)(=O)(O)N.Cl([O-])=O.[Na+]>O>[C:1]([C:3]1[O:4][C:5]2[C:6](=[C:8]([C:14]([OH:18])=[O:15])[CH:9]=[CH:10][C:11]=2[O:12][CH3:13])[CH:7]=1)#[N:2]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 5987Sulfamic AcidHCID 227342992-Cyano-7-methoxybenzofuran-4-carbaldehydeHCID 23668197Sodium Chlorite

생성물 1

HCID 227341122-Cyano-7-methoxybenzofuran-4-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of Compound IIi (0.2 g) obtained in Reference Example 9, a 80% aqueous solution (2 ml) of acetic acid, sulfamic acid (0.145 g), and a 80% aqueous solution (0.084 g) of sodium chlorite was stirred at room temperature one night. The mixture was diluted with water, and then the precipitated solid was collected by filtration and dried to give Compound IIab (0.259 g, 83%) as white crystals.

후처리

  1. customobtained in Reference Example 9
  2. filtrationthe precipitated solid was collected by filtration
  3. customdried
  4. customto give Compound IIab (0.259 g, 83%) as white crystals

출처 및 근거

ORD 기록
ord-0a6f5c275ee1488ca7fca7e3b8a0b6ae
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06514996B2

반응 노트

불러오는 중…