Guaiacol → Ethyl (2-methoxyphenoxy)acetate

HRID 1057938노트

반응식

HRID 1057938 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]

참가 물질

5

반응물 3

HCID 460GuaiacolHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

생성물 1

HCID 83114Ethyl (2-methoxyphenoxy)acetate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 2-methoxyphenol (11.3 g), potassium carbonate (25 g), ethyl bromoacetate (12 ml), and acetone (113 ml) was heated under reflux for 4 hours. After cooling to the room temperature, the mixture was filtered and the solvent was distilled off under reduced pressure from the filtrate. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1) to give Compound IIbd-a (17 g, 91%) as a pale-yellow oily substance.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. filtrationthe mixture was filtered
  4. distillationthe solvent was distilled off under reduced pressure from the filtrate
  5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1)
  6. customto give Compound IIbd-a (17 g, 91%) as a pale-yellow oily substance

출처 및 근거

ORD 기록
ord-03b4c84422e74e7cae602fc469941ece
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06514996B2

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