Water → 2-(4-Bromophenyl)-3,3,3-trifluoronitropropene
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.[CH3:14][N+:15]([O-:17])=[O:16].O>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:9]([F:12])([F:11])[F:10])=[CH:14][N+:15]([O-:17])=[O:16])=[CH:4][CH:3]=1참가 물질
5
실험 절차
A stirred solution of 4′-bromo-2,2,2-trifluoroacetophenone (0.392 g, 2.00 mmol). and CH3NO2 (0.488 g, 8.0 mmol) in dry toluene (70 mL) containing N,N-diethylenediamine (30 mmol) is heated at reflux with a Dean and Stark trap until complete removal of H2O. The cooled solution is washed with 5% aqueous HCl, dried over MgSO4, filtered, evaporated in vacuo and the resulting residue when purified by chromatography gives the title compound.
후처리
- temperatureis heated
- washThe cooled solution is washed with 5% aqueous HCl
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated in vacuo
- customthe resulting residue when purified by chromatography
출처 및 근거
- ORD 기록
- ord-6bf34d7644d3454d8bc9f17ebaa6e019
- 출처 데이터셋
- uspto-grants-2003_02
- 특허 번호
- US06515026B2
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