Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 10580생성일: 2026년 10월 24일
4-Methoxybenzylamine → 4-[1-(4-Methoxybenzyl)amino-5-isoquinolyl]amino-1-(tert-butoxycarbonyl)piperidine
https://huagongshe.com/ko/reaction/10580
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Methoxybenzylamine | HCID 75452 | — |
| 반응물 | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| 반응물 | 4-(1-Chloro-5-isoquinolyl)amino-1-(tert-butoxycarbonyl)piperidine | HCID 21979829 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-[1-(4-Methoxybenzyl)amino-5-isoquinolyl]amino-1-(tert-butoxycarbonyl)piperidine | HCID 21979935 | — |
반응 단계
A suspension of Intermediate 84 (235 mg), 4-methoxybenzylamine (110 μl), tris(dibenzylideneacetone)dipalladium(0) (30.4 mg), 2-(di-tert-butylphosphino)biphenyl (41.0 mg) and sodium tert-butoxide (93.6 mg) in toluene (4.5 ml) was stirred at 70° C. for 1 hour. The reaction mixture was filtered through a Celite layer, and the solvent was evaporated under reduced pressure. Then, the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1) to obtain the title compound (270 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07094789B2 |
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| 출처 데이터셋 | uspto-grants-2006_08 |
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| ORD ID | ord-d189c45fbcf042a78bf55612f254a951 |
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| 출처 메모 | uspto-grants-2006_08 |
|---|
