Hydrochloride methanol → 4-(1-Amino-5-isoquinolyl)aminopiperidine

HRID 10582

반응식

HRID 10582 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([NH:12][CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.Cl.CO>>[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([NH:12][CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 219797874-(1-Amino-5-isoquinolyl)amino-1-(tert-butoxycarbonyl)piperidine

생성물 1

HCID 219798644-(1-Amino-5-isoquinolyl)aminopiperidine수율 71.7%

실험 절차

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 133 (199 mg) and 10% hydrogen chloride/methanol solution (3 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (101 mg).

후처리

  1. custom(room temperature, 2 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-6a29741c4a614edab796fa123e380462
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

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