Nitric Acid → 5-Fluoro-6-nitro-2,3-dihydro-1,3-benzoxazol-2-one

HRID 1058211

반응식

HRID 1058211 반응식
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:7]=[CH:8][C:9]2[O:13][C:12](=[O:14])[NH:11][C:10]=2[CH:15]=1>O>[F:5][C:6]1[C:7]([N+:1]([O-:4])=[O:2])=[CH:8][C:9]2[O:13][C:12](=[O:14])[NH:11][C:10]=2[CH:15]=1

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 2872085-Fluoro-2(3H)-benzoxazolone

생성물 1

HCID 112178355-Fluoro-6-nitro-2,3-dihydro-1,3-benzoxazol-2-one수율 88%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

In a 500-ml flask, place 100 ml of concentrated nitric acid (70%) and warm to 45° C. Add 30.6 g (0.2 m) of 5-fluoro-benzoxazol-2-one (1a; X=F) and stir at 50° C. for 3 hrs. Add 240 ml of water slowly, and stir and cool to room temperature. Collect solid, wash with water, and dry in air to give 35.0 g (88%) of 5-fluoro-6-nitro-benzoxazol-2-one (2a; X=F) as pale yellow solids.

후처리

  1. customIn a 500-ml flask, place
  2. stirringstir
  3. temperaturecool to room temperature
  4. customCollect solid
  5. washwash with water
  6. customdry in air

출처 및 근거

ORD 기록
ord-9a5f5f647d1f4215a437c2010fcf77b0
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06515176B1

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