Methanethioamide → HCID 13015600, 화합물

HRID 1058348

반응식

HRID 1058348 반응식
[CH:1]([NH2:3])=[S:2].[CH2:4]([O:6][C:7](=[O:15])[CH:8](Cl)[C:9](=O)[CH:10]([CH3:12])[CH3:11])[CH3:5]>C(O)C>[CH2:4]([O:6][C:7]([C:8]1[S:2][CH:1]=[N:3][C:9]=1[CH:10]([CH3:12])[CH3:11])=[O:15])[CH3:5]

참가 물질

4

반응물 2

HCID 3005587MethanethioamideHCID 9877606Ethyl 2-chloro-4-methyl-3-oxopentanoate

생성물 1

HCID 13015600HCID 13015600, 화합물수율 36%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of thioformamide (prepared according to A1-Razzar et al. U.S. Pat, No. 5,559158; 1.2 g, 20 mmol) and 2-chloro-4-methyl-3-oxopentanoic acid ethyl ester (2.0 g, 10 mmol) in ethanol (20 mL) was heated at reflux for 17 h. The reaction mixture was evaporated to dryness and the residue was chromatographed over silica gel (5-20% ethyl acetate/hexanes) to give 4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester (720 mg, 36% yield).

후처리

  1. temperatureat reflux for 17 h
  2. customThe reaction mixture was evaporated to dryness
  3. customthe residue was chromatographed over silica gel (5-20% ethyl acetate/hexanes)

출처 및 근거

ORD 기록
ord-129a30faf3f14682a1471b9b795211e5
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06515124B2

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