3-Biphenylylacetic acid → 1-(Benzyloxycarbonyl-L-leucinyl)amino-3-[3-(phenyl)phenylacetyl]amino-2-propanone

HRID 1058575

반응식

HRID 1058575 반응식
[C:1]([NH:11][C@H:12]([C:17]([OH:19])=O)[CH2:13][CH:14]([CH3:16])[CH3:15])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].C([NH:27][C@H:28]([C:33]([OH:35])=O)CC(C)C)(OC(C)(C)C)=O.[C:36]1([C:42]2[CH:43]=[C:44]([CH2:48][C:49]([OH:51])=O)[CH:45]=[CH:46][CH:47]=2)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1.[N:52]1C=CC=C[C:53]=1C1C=C(CC(O)=O)C=CC=1>>[CH2:4]([O:3][C:1]([NH:11][C@H:12]([C:17]([NH:52][CH2:53][C:33](=[O:35])[CH2:28][NH:27][C:49](=[O:51])[CH2:48][C:44]1[CH:45]=[CH:46][CH:47]=[C:42]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:43]=1)=[O:19])[CH2:13][CH:14]([CH3:15])[CH3:16])=[O:2])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

참가 물질

5

반응물 4

HCID 321533-Biphenylylacetic acidHCID 74840Leucine, N-carboxy-, N-benzyl ester, L-HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-HCID 120760552-(3-(Pyridin-2-yl)phenyl)acetic acid

생성물 1

HCID 698429551-(Benzyloxycarbonyl-L-leucinyl)amino-3-[3-(phenyl)phenylacetyl]amino-2-propanone

실험 절차

Following the procedure of Example 4(a-d), except substituting “Cbz-leucine” for “Boc-leucine” and “3-(phenyl)phenylacetic acid” for “3-(2-pyridyl)phenylacetic acid” gave the title compound: MS (ES+) 530.3 (M+H+), 552.2 (M+Na+).

출처 및 근거

ORD 기록
ord-c32c423249234c44a8665575b63b682a
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518267B1

연결된 노트

불러오는 중…