Sodium Iodide → Cyclopentane, (2-iodoethoxy)-

HRID 1058753노트

반응식

HRID 1058753 반응식
BrC1C=CC(S(O[CH2:12][CH2:13][O:14][CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)(=O)=O)=CC=1.[I-:20].[Na+]>CC(C)=O>[I:20][CH2:12][CH2:13][O:14][CH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 18669129HCID 18669129, 화합물

생성물 1

HCID 18669143Cyclopentane, (2-iodoethoxy)-수율 37%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 2-(cyclopentyloxy)ethyl 4-bromobenzenesulfonate (Preparation 16, 60 mg, 0.17 mmol) in acetone (5 mL) at room temperature was added sodium iodide (200 mg, 1.3 mmol). The mixture was,heated at 35° C. for 16 hours and then cooled. The residual precipitate was removed by filtration and the filtrate was concentrated in vacuo. The residue was partitioned between diethyl ether (10 mL) and water (10 mL). The two layers were separated and the organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to give the title compound (15 mg, 37%) as a brown oil.

후처리

  1. temperaturecooled
  2. customThe residual precipitate was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo
  4. customThe residue was partitioned between diethyl ether (10 mL) and water (10 mL)
  5. customThe two layers were separated
  6. dry with materialthe organic layer was dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8b9601cdb4ce4404aeaccbdbe6e906e4
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518282B1

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