Phenylboronic Acid → Ethyl 3-[1,1'-biphenyl]-4-yl-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate

HRID 1058772노트

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([CH2:15][P:16]([OH:31])([CH:18]([NH:20][C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[CH3:19])=[O:17])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[C:32]1(B(O)O)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[C:2]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([CH2:15][P:16]([OH:31])([CH:18]([NH:20][C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[CH3:19])=[O:17])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 66827Phenylboronic Acid

HCID 18668675Ethyl 3-(4-bromophenyl)-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate

생성물 1

HCID 18668699Ethyl 3-[1,1'-biphenyl]-4-yl-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate수율 97.6%

실험 절차

The process is performed according to the operating conditions in 5.4., starting with 1.7 g (3.32 mmol) of ethyl 3-(4-bromophenyl)-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate and 4.05 g (3.32 mmol) of phenylboronic acid. 1.65 g of product are recovered (yield=97.6%).

후처리

custom1.65 g of product are recovered (yield=97.6%)

출처 및 근거

ORD 기록: ord-3349035ee4a14cdcaeb3732661193bd0
출처 데이터셋: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06518260B1

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