(-)4-[(4-Trifluoromethylphenoxy)phenyl]methyl-piperidine → (+)-4-[(4-Fluorophenoxy)phenyl]methyl-piperidine

HRID 1058777노트

반응식

HRID 1058777 반응식
[F:1]C(F)(F)C1C=CC(OC2C=CC=CC=2CC2CCNCC2)=CC=1.Cl.C([C:34]1[CH:53]=[CH:52][C:37]([O:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[CH2:45][CH:46]2[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]2)=[CH:36][CH:35]=1)(=O)C1C=CC=CC=1>>[F:1][C:34]1[CH:53]=[CH:52][C:37]([O:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[CH2:45][CH:46]2[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]2)=[CH:36][CH:35]=1

참가 물질

3

반응물 2

HCID 18669364(-)4-[(4-Trifluoromethylphenoxy)phenyl]methyl-piperidineHCID 131723762(+/-)-4-[(4-Benzoylphenoxy)phenyl]methyl-piperidine, hydrochloride

생성물 1

HCID 18669358(+)-4-[(4-Fluorophenoxy)phenyl]methyl-piperidine

실험 절차

(−)-4-[(4-trifluoromethylphenoxy)phenyl]methyl-piperidine, sulfate (96% ee, m.p.=85° C. (d), [α]365−15.5, c=0.508, CHCl3)

출처 및 근거

ORD 기록
ord-96869590de834661a91d9c472e0f64bc
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518284B2

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