Isopropyl iodide → 1-(3-Isopropoxyphenyl)piperazine

반응식

[OH:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.I[CH:22]([CH3:24])[CH3:23]>>[CH3:23][CH:22]([O:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:5]=[CH:6][CH:7]=1)[CH3:24]

참가 물질

반응물 2

HCID 6362Isopropyl iodide

HCID 18669061tert-Butyl 4-(3-hydroxyphenyl)piperazine-1-carboxylate

생성물 1

HCID 186690581-(3-Isopropoxyphenyl)piperazine

실험 절차

Prepared from 1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate (Description 21) and 2-iodopropane according to the method of Description 22. 1H NMR (250 MHz, CDCl3) δ1.34 (6H, d, J 6 Hz), 3.63-3.78 (8H, m), 4.51-4.60 (1H, m), 6.78-6.84 (2H, m), and 7.30-7.37 (1H, m).

출처 및 근거

ORD 기록: ord-2e9ab042496d41519b8779ada9183572
출처 데이터셋: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06518273B1

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