Pyridinium chloride → HCID 178474039, 화합물

HRID 1059178노트

반응식

HRID 1059178 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:42])([C:18]3[N:19]=[CH:20][N:21](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:22]=3)[CH:15]([CH3:17])[CH3:16])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[NH:43][C:44](=[O:46])[CH3:45].Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:42])([C:18]3[N:19]=[CH:20][NH:21][CH:22]=3)[CH:15]([CH3:16])[CH3:17])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[NH:43][C:44](=[O:46])[CH3:45]

참가 물질

3

반응물 2

HCID 10176127Pyridinium chlorideHCID 18668557N-{4-fluoro-4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl}acetamide

생성물 1

HCID 178474039HCID 178474039, 화합물수율 51.3%

실험 절차

By the reaction in the same manner as in Example 4-(iii) using N-{4-fluoro-4′-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1′-biphenyl]-3-yl}acetamide (1.29 g) and pyridine hydrochloride (297 mg), the title compound (399 mg) was obtained as a colorless amorphous powder.

후처리

  1. customBy the reaction in the same manner as in Example

출처 및 근거

ORD 기록
ord-ae50747066ed40f89b849a237d9aa93a
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518257B1

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