Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(3-bromobenzyl)acetamide → N-({4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl}methyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(3-bromobenzyl)acetamide | HCID 12175281 | — |
| 반응물 | 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid | HCID 18668578 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 생성물 | N-({4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl}methyl)acetamide | HCID 18668643 | 44.5% |
반응 단계
By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (3.30 g), N-(3-bromobenzyl)acetamide (1.05 g) and tetrakis(triphenylphosphine)palladium(0) (0.18 g), the title compound (1.24 g) was obtained as a pale-yellow amorphous powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06518257B1 |
| 출처 데이터셋 | uspto-grants-2003_02 |
| ORD ID | ord-02c601fc49ec4c4b9b7d34a82e078350 |
| 출처 메모 | uspto-grants-2003_02 |