Pyridinium chloride → HCID 178474326, 화합물

HRID 1059244노트

반응식

HRID 1059244 반응식
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[C:40]([NH:42][C:43](=[O:45])[CH3:44])[CH:39]=[CH:38][N:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:41]=[C:40]([NH:42][C:43](=[O:45])[CH3:44])[CH:39]=[CH:38][N:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:4])[CH3:5]

참가 물질

3

반응물 2

HCID 10176127Pyridinium chlorideHCID 18668540N-(2-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-4-pyridyl)acetamide

생성물 1

HCID 178474326HCID 178474326, 화합물수율 43%

실험 절차

By the reaction in the same manner as in Example 4-(iii) using N-(2-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-4-pyridyl)acetamide (0.590 g) and pyridine hydrochloride (190 mg), the title compound (150 mg) was obtained as colorless powder crystals.

후처리

  1. customBy the reaction in the same manner as in Example

출처 및 근거

ORD 기록
ord-90dc3c7462264da58e301023ea8c6584
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518257B1

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