Sodium Carbonate → 4'-Fluoro-2-methoxy-1,1'-biphenyl

HRID 1059253노트

반응식

HRID 1059253 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[F:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:9][O:8][C:3]1[C:2]([C:14]2[CH:15]=[CH:16][C:11]([F:10])=[CH:12][CH:13]=2)=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 113582-BromoanisoleHCID 2856454-Fluorophenylboronic acid

생성물 1

HCID 130895414'-Fluoro-2-methoxy-1,1'-biphenyl수율 84.5%

시약·촉매·용매 1

HCID 178418397HCID 178418397, 화합물촉매

실험 절차

By the reaction in the same manner as in Example 4-(ii) using 2-bromoanisole (8.91 g), 4-fluorophenylboronic acid (10.0 g), 2M aqueous sodium carbonate solution (47.6 ml) and tetrakis(triphenylphosphine)palladium(0) (2.20 g), the title compound (8.14 g) was obtained as colorless needle crystals.

후처리

  1. customBy the reaction in the same manner as in Example

출처 및 근거

ORD 기록
ord-a689a4a845844721b3654600a706b84d
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518257B1

반응 노트

불러오는 중…