Ethyl 4-(piperidin-4-yl)-2-methylbutanoate → Ethyl 4-[1-[2-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)ethyl]piperidin-4-yl]-2-methylbutanoate

HRID 1059368노트

반응식

HRID 1059368 반응식
CS(O[CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]2[S:16][C:15]3[N:17]=[CH:18][CH:19]=[N:20][C:14]=3[N:13](COC)[C:12]=2[CH:24]=1)(=O)=O.[NH:25]1[CH2:30][CH2:29][CH:28]([CH2:31][CH2:32][CH:33]([CH3:39])[C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:27][CH2:26]1.CC(CC)C([O-])=O>>[N:20]1[C:14]2[NH:13][C:12]3[CH:24]=[C:8]([CH2:7][CH2:6][N:25]4[CH2:30][CH2:29][CH:28]([CH2:31][CH2:32][CH:33]([CH3:39])[C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:27][CH2:26]4)[CH:9]=[CH:10][C:11]=3[S:16][C:15]=2[N:17]=[CH:18][CH:19]=1

참가 물질

4

반응물 3

HCID 11298836Ethyl 4-(piperidin-4-yl)-2-methylbutanoateHCID 186705792-[10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl]ethyl methanesulfonateHCID 222532972-Methylbutyrate

생성물 1

HCID 11476192Ethyl 4-[1-[2-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)ethyl]piperidin-4-yl]-2-methylbutanoate

실험 절차

Starting with 2-[10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl]ethyl methanesulfonate and ethyl 4-(piperidin-4-yl)-2-methylbutanoate, ethyl 4-[1-[2-10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-ethyl]piperidin-4-yl]-2-methylbutanoate was obtained by the same method as the one of Example 63. Next, this product was treated by the same method as the one of Example 8 to thereby give the title compound.

후처리

  1. customwas obtained by the same method as the one of Example 63
  2. additionNext, this product was treated by the same method as the one of Example 8

출처 및 근거

ORD 기록
ord-424e495ea4874f809cd54e17529a9b86
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518423B1

반응 노트

불러오는 중…